Publications

R I C

Click here to edit subtitle

Computational Modelling and Bioinformatics Study For 
Evaluation of Oligomerization of Protein Structures in
Different Living Species 

Author(s): 

JAYESH PATEL 

EMANUAL MICHAEL PATELIA

DR. GUY GRANT


ISBN:

978-0-9895590-4-1 


Publisher:

ORIC Publications


Publishing Date:

September, 2014


Publishing Category:

Thesis Publishing


Pages:

35



Table of Content

Preview on the Google Books

Book Summary


Oligomerization of protein plays important role in various proteins function. In this manner, understanding, foreseeing, and, at last, building oligomerization exhibits a long-standing interest. From the viewpoint of structural science, protein–protein interactions have fundamentally been dissected regarding the biophysical nature and development of protein interfaces. Here, my point is to quantify the essentialness of the bigger structural connection of protein interfaces in protein evolution and its cooperation. Specifically, I ask to what degree intersubunit geometry influences oligomerization state. I characterize a set of structural parameters depicting the general geometry and relative positions of interfaces of homomeric complexes with various oligomeric states. This permits us to quantify the commitment of immediate sequence changes in interfaces versus indirect changes outside the interface that influence intersubunit geometry. I found that such indirect or allosteric changes influencing intersubunit geometry through indirect mechanism has equal importance as interface sequence mutation for evolution of oligomeric states of structures.